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November 11, 2020
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HMGB1 mediates homocysteine-induced endothelial cells pyroptosis via cathepsin V-dependent pathway

HMGB1 mediates homocysteine-induced endothelial cells pyroptosis via cathepsin V-dependent pathway

Endothelial cells harm and pro-inflammation cytokines launch are the preliminary steps of hyperhomocysteinemia (HHcy)-associated vascular irritation. Pyroptosis is a newly recognized pro-inflammation type of programmed cell demise, inflicting cell lysis and IL-1β launch, and characterised by the caspases-induced cleavage of its effector molecule gasdermins (GSDMs). Nonetheless, the impact of homocysteine (Hcy) on endothelial cells pyroptosis […]

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